AKRIBES INNOVATION

ASSAY PLATFORM WITH WOUND-SPECIFIC CELL TYPES

Cell types and their role in wounds
Focus on fibroblasts because the hole of the wound needs
to be filled with new tissue before it can be closed.

FIBROBLAST PROLIFERATION ASSAY:
MINIATURIZED ASSAY IN LAB-ON-A-CHIP FORMAT

There is a causal link between wound chronicity and detrimental effects of wound exudates on primary human fibroblasts.

Progression from a non-healing to a healing wound is linked with the restauration of proliferation and reduction of IL-1ß secretion.

Goal: To identify compounds which reverse the detrimental effects of chronic wound exudates on primary human cells.

NEW WOUND HEALING THERAPEUTICS

IDENTIFICATION OF A POTENTIAL WOUND HEALING THERAPEUTIC

AKR101 rescues fibroblasts from wound fluid-induced damage

Quantification of the rescue-effect of AKR101
(readout from a plate reader)

AKRIBES PIPELINE

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